The impacts of the COVID-19 pandemic on the lives and livelihoods of the most vulnerable people are enormous, both in terms of the number of people infected and the profound economic crisis that has been unleashed. Individuals and population groups who were already suffering from violence, stigma, discrimination and unequal access to basic services and living conditions are bearing the brunt of this new crisis. The COVID-19 Global Humanitarian Response Plan (GHRP) analyses and responds to the direct public health and indirect humanitarian consequences of the pandemic, particularly on people in countries already facing other crises.