The COVID-19 pandemic has revealed massive inequalities within our societies and has brought to light the unique burdens that women globally carry. As we respond to the impacts of COVID-19, both in the immediate and long term, we have an unprecedented opportunity to completely redesign our ways of living through innovative and large-scale action that can cater for the magnitude of transforming the African continent. The allocation of response resources should be dually focused on the immediate needs of managing the virus and, simultaneously, on the future, to dismantle the structural and systemic barriers that reinforce inequality and disenfranchisement. We have been presented with the opportunity to reimagine and redesign our society into one that is vibrant and equitable. We must place women at the core of the response and beyond.